Professor Dilly OC Anumba
FRCOG, MD (Newcastle upon Tyne), LLM Medical Law (Northumbria)
Dilly is Professor of Obstetrics and Gynaecology at University of Sheffield. His research explores the physiology of pregnancy and birth, with particular focus on devices for predicting premature birth, and the immunological mechanisms of diseases (egpreeclampsia and fetal disease) that contribute to this principal cause of perinatal mortality and morbidity. Dilly investigates the assessment of the cervical remodeling that precedes premature birth, seeking to understand how this is influenced by its immunological/structural properties, andto translate such knowledge into clinical utility. A key goal is to develop means of predicting premature birth that would fit into current clinical care pathways, thus informing its prevention and mitigating its consequences.
ECCLIPPx is the research programme that explores electrical impedance spectroscopy (EIS)(1-3), and several other innovative techniques and devices,for predicting preterm birth. The group’s early work focussed on clinical experimentation to ascertain the EIS device configuration for optimal capture of cervical tissue electrical resistivity(4, 5), ascertaining and improving device accuracy, assessing labour inducibility prior to birth(6, 7), and more recently, generating preliminary proof-of-principle experiments exploring the potential application of EIS, amongst other techniques, for predicting preterm birth(8). The project strands are currently supported by Grants from the UK’s Medical Research Council Developmental Pathways Funding Scheme (MRC DPF/DCS, £622,047.73, 2012-2016), and the Department of Health’s National Institute of Health Research Invention for Innovation (i4i) scheme (£320,138.00, 2012-2015).
Selected relevant publications
- O'Connell MP, Avis NJ, Brown BH, Killick SR, Lindow SW. Electrical impedance measurements: an objective measure of prelabor cervical change. J Matern Fetal Neonatal Med. 2003 Dec;14(6):389-91. PubMed PMID: 15061317. eng.
- O'Connell MP, Tidy J, Wisher SJ, Avis NJ, Brown BH, Lindow SW. An in vivo comparative study of the pregnant and nonpregnant cervix using electrical impedance measurements. Bjog. 2000 Aug;107(8):1040-1. PubMed PMID: 10955439. eng.
- Avis NJ, Lindow SW, Kleinermann F. In vitro multifrequency electrical impedance measurements and modelling of the cervix in late pregnancy. Physiol Meas. 1996 Nov;17 Suppl 4A:A97-103. PubMed PMID: 9001608. eng.
- Gandhi SV, Walker D, Milnes P, Mukherjee S, Brown BH, Anumba DO. Electrical impedance spectroscopy of the cervix in non-pregnant and pregnant women. Eur J Obstet Gynecol Reprod Biol. 2006 Dec;129(2):145-9. PubMed PMID: 16517044. eng.
- Gandhi SV, Walker DC, Brown BH, Anumba DO. Comparison of human uterine cervical electrical impedance measurements derived using two tetrapolar probes of different sizes. Biomed Eng Online. 2006;5:62. PubMed PMID: 17125510. eng.
- Jokhi RP, Ghule VV, Brown BH, Anumba DO. Reproducibility and repeatability of measuring the electrical impedance of the pregnant human cervix-the effect of probe size and applied pressure. Biomed Eng Online. 2009;8:10. PubMed PMID: 19534806. Pubmed Central PMCID: 2704213. Epub 2009/06/19. eng.
- Jokhi RP, Brown BH, Anumba DO. The role of cervical Electrical Impedance Spectroscopy in the prediction of the course and outcome of induced labour. BMC pregnancy and childbirth. 2009;9:40. PubMed PMID: 19725953. Epub 2009/09/04. eng.
- Anumba DO, Jokhi RP, Ghule V, Healey J, Brown BH. Cervical Electrical Impedance Spectroscopy May Predict Preterm Delivery in Women at Risk. Reprod Sci. 2011;18(3):301A-A.