The Project

The Technology - Electrical Impedance Spectroscopy

Electrical impedance spectroscopy (EIS) involves the measurement of transfer impedance over a range of frequencies, and to estimate the tissue’s complex impedivity. Our probe design can provide, by the surrogate of a transfer impedance measurement, information on the cellular structure of the tissue.  Several members of our group have used this principle to develop a screening technique for cervical pre-cancer. Since impedance spectra are determined mainly by the cellular and matrix structure of tissue, we have hypothesised that the changes in impedance of cervical tissue during pregnancy will reflect tissue composition and remodelling during pregnancy. We have therefore been studying the potential predictive utility of measuring EIS of the cervix for predicting preterm birth.